SCHEMBL7404277

SCHEMBL7404277

O=C1CC(OC(=O)C2CCO2)C(=O)N1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAP3K14 Q99558 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MEN1 O00255 1/20 0.33
APEX1 P27695 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
DDB1 Q16531 3/20 0.31
CRBN Q96SW2 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4827454 0.81 MAP3K14 (0.32) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL1421996 0.77 CHRM2 (0.39) MAP3K14KDM4EHPGDHSD17B10MEN1
SCHEMBL7404275 0.77 MAP3K14 (0.33) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL3949247 0.74 MAP3K14 (0.40) MAP3K14KDM4EALDH1A1MEN1APEX1
SCHEMBL7264550 0.74 MAP3K14 (0.40) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL28608528 0.73 MEN1 (0.40) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL57232 0.73 MAP3K14 (0.39) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL7530544 0.73 MAP3K14 (0.39) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL2782193 0.73 MEN1 (0.40) MAP3K14MEN1APEX1KMT2ATDP1
SCHEMBL5499487 0.72 GLA (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0632808-A1 ANTIVIRAL PEPTIDES Pfizer Limited (GB) 1995-01-11 EP disclosed
WO-1993019059-A1 ANTIVIRAL PEPTIDES PFIZER LIMITED (GB) 1993-09-30 WO disclosed