SCHEMBL7405256

SCHEMBL7405256

O=C(O)Nc1csc2cc(OCc3ccccc3)ccc12

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 3/20 0.48
PPARA Q07869 3/20 0.48
PPARG P37231 2/20 0.48
FFAR1 O14842 1/20 0.46
NPC1 O15118 5/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
TNKS2 Q9H2K2 1/20 0.46
PARP2 Q9UGN5 1/20 0.46
RAB9A P51151 4/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
MAOB P27338 2/20 0.44
LTA4H P09960 1/20 0.44
NR4A2 P43354 2/20 0.44
P2RY14 Q15391 1/20 0.44
NR4A1 P22736 1/20 0.43
NR4A3 Q92570 1/20 0.43
ACHE P22303 1/20 0.43
SMPD1 P17405 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8436763 0.79 PKM (0.44) PPARGNPC1MEN1KMT2ARAB9A
SCHEMBL7402777 0.77 MAOB (0.48) PPARDPPARAPPARGMAOB
SCHEMBL5441264 0.77 MAOB (0.51) PPARDPPARAPPARGTNKS2PARP2
SCHEMBL8695194 0.77 PPARD (0.58) PPARDPPARAPPARGFFAR1
SCHEMBL8303707 0.77 SMPD1 (0.45) NPC1MEN1KMT2ATNKS2PARP2
SCHEMBL7405156 0.75 MAPT (0.45) NPC1MEN1KMT2ATNKS2PARP2
SCHEMBL7405860 0.75 MAOB (0.52) PPARDPPARAPPARGFFAR1NPC1
SCHEMBL15876017 0.75 NPC1 (0.56) NPC1MEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL8694064 0.75 PPARD (0.53) PPARDPPARAPPARGFFAR1TNKS2
SCHEMBL4476253 0.74 MAOB (0.66) NPC1MEN1KMT2ARAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5969146-A MONOAMINE OXIDASE INHIBITORS SYNTHELABO (FR) 1999-10-19 US disclosed
EP-0891358-A1 OXAZOLIDIN-2-ONE DERIVATIVES, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF SYNTHELABO (FR) 1999-01-20 EP disclosed
WO-1997013768-A1 OXAZOLIDIN-2-ONE DERIVATIVES, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF SYNTHELABO (FR) 1997-04-17 WO disclosed