Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.39 |
| ▸ | MME | P08473 | 6/20 | 0.39 |
| ▸ | CPA1 | P15085 | 4/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | FCER2 | P06734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408172 | 0.85 | HRH4 (0.45) | ACEMMECPA1ACE2MEN1 | |
| SCHEMBL7419934 | 0.84 | MME (0.53) | ACEMMECPA1ACE2MEN1 | |
| SCHEMBL7416436 | 0.81 | MME (0.51) | ACEMMECPA1ACE2MMP1 | |
| SCHEMBL7405258 | 0.78 | PIN1 (0.53) | ACEMMECPA1ACE2MEN1 | |
| SCHEMBL7405261 | 0.78 | PIN1 (0.53) | ACEMMECPA1ACE2MEN1 | |
| SCHEMBL7410932 | 0.77 | ACE (0.61) | ACE | |
| SCHEMBL7407660 | 0.75 | ACE (0.53) | ACEMMECPA1ACE2 | |
| SCHEMBL7409095 | 0.75 | ACE (0.53) | ACEMMECPA1ACE2 | |
| SCHEMBL7407664 | 0.75 | ACE (0.53) | ACEMMECPA1ACE2 | |
| SCHEMBL7409087 | 0.75 | ACE (0.53) | ACEMMECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5414013-A | Enzyme inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5414017-A | Cardiovascular agents | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5223516-A | Endopeptidase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0449523-A1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | E.R. SQUIBB & SONS, INC. (US) | 1991-10-02 | — | — | EP | disclosed |