Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | ECE1 | P42892 | 9/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11430738 | 0.87 | ACE (0.67) | ACEALOX15ECE1 | |
| SCHEMBL7322267 | 0.86 | ACE (0.73) | ACEALOX15ECE1 | |
| SCHEMBL7410432 | 0.85 | ACE (0.71) | ACEECE1 | |
| SCHEMBL7419934 | 0.84 | MME (0.53) | ACEECE1 | |
| SCHEMBL6172199 | 0.83 | LTA4H (0.69) | ACEALOX15ECE1 | |
| SCHEMBL6172205 | 0.83 | LTA4H (0.69) | ACEALOX15ECE1 | |
| SCHEMBL9068531 | 0.82 | ECE1 (0.75) | ACEALOX15ECE1 | |
| SCHEMBL7416436 | 0.81 | MME (0.51) | ACEECE1 | |
| SCHEMBL7411840 | 0.81 | MMP1 (0.43) | ACEALOX15 | |
| SCHEMBL7411850 | 0.81 | MMP1 (0.43) | ACEALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5414013-A | Enzyme inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5414017-A | Cardiovascular agents | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5223516-A | Endopeptidase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0449523-A1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | E.R. SQUIBB & SONS, INC. (US) | 1991-10-02 | — | — | EP | disclosed |