Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409384 | 0.86 | F10 (0.53) | CHEK2PKMPOLBF10F2 | |
| SCHEMBL7407342 | 0.82 | CDK1 (0.45) | F10F2GFERPRSS1PRSS2 | |
| SCHEMBL7405344 | 0.79 | F2 (0.55) | CHEK2PKMF10F2GNRHR | |
| SCHEMBL3830602 | 0.78 | F10 (0.47) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7403000 | 0.77 | F10 (0.58) | POLBF10F2PRSS1PRSS2 | |
| SCHEMBL7406132 | 0.77 | ALDH1A1 (0.46) | CHEK2POLBLMNAF10F2 | |
| SCHEMBL7407083 | 0.76 | IDO1 (0.50) | PKMLMNAF10F2PRSS1 | |
| SCHEMBL7404851 | 0.76 | MLKL (0.45) | F10F2MAPK1RAB9APRSS1 | |
| SCHEMBL7503638 | 0.76 | F2 (0.59) | CHEK2F10F2PRSS1PRSS2 | |
| SCHEMBL7405075 | 0.76 | F2 (0.44) | CHEK2F10F2GFERPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999026932-A1 | BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |