Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3069505 | 0.84 | FKBP5 (0.42) | FKBP5GAAMAPTTSHR | |
| SCHEMBL11650294 | 0.76 | ESR1 (0.46) | CA2CA4CA5AFKBP5ESR1 | |
| SCHEMBL132983 | 0.75 | LMNA (0.60) | LMNACA2CA4CA5AESR1 | |
| SCHEMBL5439069 | 0.75 | LMNA (0.60) | LMNACA2CA4CA5AESR1 | |
| SCHEMBL5436616 | 0.75 | LMNA (0.60) | LMNACA2CA4CA5AESR1 | |
| Triphenylphosphine Oxide SCHEMBL513223 | 0.72 | CA2 (0.58) | LMNACA2CA4CA5AESR1 | |
| Triphenylphosphine Oxide SCHEMBL3949 | 0.72 | CA2 (0.58) | LMNACA2CA4CA5AESR1 | |
| SCHEMBL5444731 | 0.71 | LMNA (0.56) | LMNACA2CA4CA5AESR1 | |
| SCHEMBL4774848 | 0.71 | LMNA (0.56) | LMNACA2CA4CA5AESR1 | |
| SCHEMBL22174892 | 0.71 | LMNA (0.56) | LMNACA2CA4CA5AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777650-B1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-03-07 | — | — | EP | disclosed |
| US-5952325-A | Tricyclic spiro compounds process for their preparation and their use of 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1999-09-14 | — | — | US | disclosed |
| US-5905080-A | Amide and urea derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-05-18 | — | — | US | disclosed |
| EP-0712397-B1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-04-21 | — | — | EP | disclosed |
| US-5889022-A | Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-03-30 | — | — | US | disclosed |
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | disclosed |
| US-5834471-A | Amide derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0752982-B1 | BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-14 | — | — | EP | disclosed |
| US-5817833-A | Biphenylamide compounds as 5HT1D Antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-10-06 | — | — | US | disclosed |
| US-5801170-A | Heterocyclic biphenylylamides useful as 5HT1D antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-09-01 | — | — | US | disclosed |
| WO-1995030675-A1 | BIPHENYLCARBOXAMIDES USEFUL AS 5-HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-11-16 | — | — | WO | disclosed |
| WO-1995026328-A1 | BIPHENYL DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-05 | — | — | WO | disclosed |
| WO-1995017398-A1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT1D (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |
| WO-1995017401-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |
| WO-1995015954-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-15 | — | — | WO | disclosed |
| WO-1995011243-A1 | BENZANILIDE DERIVATIVES AS 5HT-1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-04-27 | — | — | WO | disclosed |
| WO-1995006644-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | disclosed |
| WO-1995006637-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | disclosed |
| WO-1995006044-A1 | AMIDE AND UREA DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-02 | — | — | WO | disclosed |
| WO-1995004729-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-16 | — | — | WO | disclosed |