Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19388177 | 0.91 | ATM (0.44) | APOBEC3ARECQLAPOBEC3GATMALDH1A1 | |
| SCHEMBL11010892 | 0.86 | CYP3A4 (0.46) | ALDH1A1POLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25924384 | 0.86 | ATM (0.39) | APOBEC3ARECQLAPOBEC3GATMALDH1A1 | |
| SCHEMBL7405996 | 0.85 | APOBEC3A (0.39) | APOBEC3ARECQLAPOBEC3GALDH1A1POLB | |
| SCHEMBL1289870 | 0.83 | SLC1A2 (0.50) | ATMALDH1A1IL1RNERAP2ERAP1 | |
| SCHEMBL21960350 | 0.83 | CTSB (0.47) | ATMALDH1A1IL1RNERAP2ERAP1 | |
| SCHEMBL21960352 | 0.83 | CTSB (0.47) | ATMALDH1A1IL1RNERAP2ERAP1 | |
| SCHEMBL27058220 | 0.82 | ALDH1A1 (0.42) | ATMALDH1A1IL1RNERAP2ERAP1 | |
| SCHEMBL3736402 | 0.81 | ALDH1A1 (0.47) | ATMALDH1A1IL1RNERAP2ERAP1 | |
| SCHEMBL9782615 | 0.81 | ALDH1A1 (0.46) | APOBEC3ARECQLAPOBEC3GALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482827-B1 | Matrix metalloproteinase inhibitors | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-11-19 | — | — | US | disclosed |
| EP-0925289-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-06-30 | — | — | EP | disclosed |
| EP-0920414-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-06-09 | — | — | EP | disclosed |
| WO-1999002510-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-01-21 | — | — | WO | disclosed |
| WO-1997049674-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-12-31 | — | — | WO | disclosed |