Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410875 | 0.90 | DRD2 (0.50) | DRD2HTR1AHTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL7413705 | 0.88 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL7413702 | 0.88 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL7415382 | 0.85 | DRD2 (0.47) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL7412531 | 0.84 | DRD2 (0.47) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL7413539 | 0.80 | DRD2 (0.51) | DRD2HTR1AHTR2ADRD3DRD1 | |
| Hydrochloric Acid SCHEMBL7410797 | 0.79 | DRD2 (0.51) | DRD2HTR1ATMEM97SIGMAR1HTR7 | |
| SCHEMBL7418258 | 0.79 | HRH3 (0.46) | DRD2HTR1AHTR2ADRD3HRH1 | |
| SCHEMBL7409358 | 0.79 | EPHX2 (0.41) | DRD2HTR1AHTR2ADRD3HRH1 | |
| SCHEMBL7458788 | 0.79 | SLC6A4 (0.52) | CCR3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198449-A | N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents | A. H. ROBINS COMPANY INCORPORATED (US) | 1993-03-30 | — | — | US | disclosed |