Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407387 | 0.76 | CHRNB2 (0.43) | CHRNB2CHRNA4TACR1SLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL7411065 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4TACR1SLC6A4KCNH2 | |
| SCHEMBL7412587 | 0.73 | CHRNB2 (0.42) | CHRNB2CHRNA4TACR1SLC6A4KCNH2 | |
| SCHEMBL21675841 | 0.69 | MAOB (0.62) | HTTRAB9A | |
| Hydrochloric Acid SCHEMBL7413367 | 0.68 | CHRNB2 (0.39) | CHRNB2CHRNA4TACR1SLC6A4KCNH2 | |
| SCHEMBL1622035 | 0.67 | CHRNB2 (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL28824360 | 0.65 | HTT (0.47) | KCNH2HTTRAB9A | |
| SCHEMBL2185911 | 0.64 | DGAT1 (0.37) | CHRNB2CHRNA4RAB9A | |
| SCHEMBL2300520 | 0.64 | DGAT1 (0.37) | CHRNB2CHRNA4RAB9A | |
| SCHEMBL16855810 | 0.64 | RAB9A (0.55) | HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1997046554-A1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1997-12-11 | — | — | WO | disclosed |