Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 5/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742020 | 0.84 | HRH1 (0.50) | CHRM1HRH1RENKMT2ANPY1R | |
| SCHEMBL742021 | 0.84 | HRH1 (0.50) | CHRM1HRH1RENKMT2ANPY1R | |
| SCHEMBL740511 | 0.80 | CHRM1 (0.48) | CHRM1HRH1RENACP1 | |
| SCHEMBL739843 | 0.80 | HRH1 (0.70) | CHRM1HRH1RENNPY1ROPRM1 | |
| SCHEMBL739842 | 0.80 | HRH1 (0.70) | CHRM1HRH1RENNPY1ROPRM1 | |
| SCHEMBL741659 | 0.79 | PARP1 (0.42) | PARP1LMNA | |
| Piperidine SCHEMBL742276 | 0.77 | HRH1 (0.67) | CHRM1HRH1RENNPY1ROPRM1 | |
| SCHEMBL740713 | 0.73 | HRH1 (0.53) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL741971 | 0.73 | HRH1 (0.53) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL740862 | 0.73 | CHRM1 (0.46) | CHRM1HRH1RENNPY1ROPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |