Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | NPY1R | P25929 | 9/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742021 | 1.00 | HRH1 (0.50) | HRH1CHRM1NPY1RRENOPRM1 | |
| SCHEMBL741173 | 0.84 | CHRM1 (0.50) | HRH1CHRM1NPY1RRENCCNT1 | |
| SCHEMBL741172 | 0.84 | CHRM1 (0.50) | HRH1CHRM1NPY1RRENCCNT1 | |
| SCHEMBL740746 | 0.84 | CHRM1 (0.46) | HRH1CHRM1NPY1RRENOPRM1 | |
| SCHEMBL739843 | 0.83 | HRH1 (0.70) | HRH1CHRM1NPY1RRENOPRM1 | |
| SCHEMBL739842 | 0.83 | HRH1 (0.70) | HRH1CHRM1NPY1RRENOPRM1 | |
| SCHEMBL741000 | 0.82 | CHRM1 (0.49) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL741001 | 0.82 | CHRM1 (0.49) | HRH1CHRM1RENOPRM1OPRD1 | |
| SCHEMBL740862 | 0.81 | CHRM1 (0.46) | HRH1CHRM1NPY1RRENOPRM1 | |
| Piperidine SCHEMBL742276 | 0.81 | HRH1 (0.67) | HRH1CHRM1NPY1RRENOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |