SCHEMBL7407474

SCHEMBL7407474

CCc1ccc(OC[C@@H]2CCN2C)cn1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 5/20 0.68
CHRNB2 P17787 6/20 0.59
CHRNA4 P43681 6/20 0.59
CHRNB4 P30926 4/20 0.59
CHRNB1 P11230 3/20 0.59
CHRNB3 Q05901 3/20 0.59
CHRNA1 P02708 1/20 0.52
CHRNA7 P36544 1/20 0.52
DAPK3 O43293 1/20 0.49
ROCK2 O75116 1/20 0.49
PRKCG P05129 1/20 0.49
PIM1 P11309 1/20 0.49
RPS6KB1 P23443 1/20 0.49
AKT1 P31749 1/20 0.49
LIMK1 P53667 1/20 0.49
CDK5 Q00535 1/20 0.49
PRKCD Q05655 1/20 0.49
PAK1 Q13153 1/20 0.49
STK3 Q13188 1/20 0.49
ROCK1 Q13464 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7465393 0.99 CHRNA3 (0.67) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL7410490 0.82 CHRNA3 (0.84) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL8437376 0.82 CHRNA3 (0.84) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL7414235 0.81 CHRNA3 (0.70) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL7911829 0.81 CHRNA3 (1.00) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL7407318 0.81 CHRNA3 (1.00) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
Hydrochloric Acid SCHEMBL7405817 0.81 CHRNB2 (0.82) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL7911837 0.81 CHRNA3 (1.00) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
Hydrochloric Acid SCHEMBL7457251 0.80 CHRNA3 (0.97) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1
SCHEMBL7461833 0.80 CHRNA3 (0.68) CHRNA3CHRNB2CHRNA4CHRNB4CHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed