Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740947 | 0.83 | MEN1 (0.47) | HPGDALDH1A1POLB | |
| SCHEMBL742645 | 0.76 | RAB9A (0.42) | HPGDALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL3723522 | 0.71 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1GAAPKM | |
| Hydrochloric Acid SCHEMBL6998897 | 0.70 | ALDH1A1 (0.60) | ALDH1A1LMNAL3MBTL1GAAPKM | |
| SCHEMBL15321741 | 0.69 | BCHE (0.50) | HPGDALDH1A1LMNAGAANPC1 | |
| SCHEMBL4755206 | 0.68 | POLB (0.52) | ALDH1A1KDM4EPOLBL3MBTL1GAA | |
| SCHEMBL740750 | 0.68 | RHOA (0.47) | HPGDALDH1A1LMNAPOLBRAB9A | |
| SCHEMBL6790893 | 0.68 | ALDH1A1 (0.41) | ALDH1A1POLB | |
| SCHEMBL2199482 | 0.68 | ALDH1A1 (0.53) | HPGDALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL4021117 | 0.68 | ALDH1A1 (0.43) | HPGDALDH1A1LMNAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |