Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497972 | 1.00 | PTGS2 (0.47) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL11837114 | 0.88 | ATM (0.50) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL11837128 | 0.88 | ATM (0.50) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL8200453 | 0.85 | AHR (0.48) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL9848580 | 0.83 | ALDH1A1 (0.61) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL11264895 | 0.83 | TSHR (0.53) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL11264900 | 0.83 | TSHR (0.53) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL8957884 | 0.83 | ALDH1A1 (0.61) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL6616919 | 0.82 | PTGS2 (0.40) | PTGS2TDP1ATMMAPTALDH1A1 | |
| SCHEMBL6616923 | 0.82 | PTGS2 (0.40) | PTGS2TDP1ATMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1097460-C | Cytotoxic amino sugars and related sugar derivatives of indolopyrrolocarbazoles | BRISTOL MYERS SQUIBB CO (US) | 2003-01-01 | — | — | CN | disclosed |
| EP-0971717-B1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0971717-A4 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0971717-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | Bristol-Myers Squibb Company (US) | 2000-01-19 | — | — | EP | disclosed |
| CN-1228704-A | Cytotoxic amino sugars and related sugar derivatives of indolopyrrolocarbazoles | BRISTOL MYERS SQUIBB CO (US) | 1999-09-15 | — | — | CN | disclosed |
| US-5929072-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-27 | — | — | US | disclosed |
| EP-0897921-A1 | Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands | ELI LILLY AND COMPANY LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |
| WO-1998007433-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |
| US-4904684-A | 2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydropyrrolo[3,2,1-hi]indole derivatives useful as antidiabetic agents | SYNTHELABO (FR) | 1990-02-27 | — | — | US | disclosed |