Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | CCR5 | P51681 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 8/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404986 | 0.82 | DRD2 (0.61) | DRD2CCR5DRD4GRM2CCR2 | |
| SCHEMBL9311044 | 0.81 | DRD2 (0.66) | DRD2DRD4GRM2 | |
| SCHEMBL4823773 | 0.75 | DRD2 (1.00) | DRD2DRD4GRM2HTR2C | |
| SCHEMBL7401247 | 0.75 | HRH3 (0.58) | DRD2 | |
| SCHEMBL9667283 | 0.74 | CHRM4 (0.69) | DRD2DRD4GRM2CHRM4HTR2C | |
| Bromide SCHEMBL5888839 | 0.74 | HRH3 (0.57) | DRD2 | |
| SCHEMBL10475673 | 0.73 | DRD2 (0.65) | DRD2CCR5DRD4GRM2CHRM4 | |
| SCHEMBL4824740 | 0.73 | DRD2 (0.85) | DRD2DRD4GRM2HTR2C | |
| SCHEMBL6351172 | 0.73 | CHRM4 (0.61) | DRD2DRD4GRM2CCR2CHRM4 | |
| SCHEMBL9422688 | 0.73 | DRD2 (0.63) | DRD2DRD4GRM2CHRM4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869792-A4 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 1999-09-22 | — | — | EP | disclosed |
| EP-0869792-A2 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023216-A1 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-07-03 | — | — | WO | disclosed |