Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403808 | 0.82 | HTR6 (0.45) | HTR6HRH1PTGS2HDAC1HDAC6 | |
| SCHEMBL7409172 | 0.82 | HDAC1 (0.42) | HTR6PTGS2HDAC1HDAC6PTGDR2 | |
| SCHEMBL3859121 | 0.76 | HTR6 (0.67) | HTR6HRH1PTGS2PTGDR2 | |
| SCHEMBL7409734 | 0.75 | MAPT (0.47) | HTR6LMNAHTT | |
| SCHEMBL3140058 | 0.70 | HTR6 (0.59) | HTR6HRH1EGFRIGF1RFLT4 | |
| SCHEMBL28074399 | 0.70 | HDAC6 (0.49) | EGFRIGF1RFLT4KDRHDAC6 | |
| SCHEMBL7411294 | 0.69 | DRD3 (0.58) | HTR6HDAC1HDAC6PTGDR2KDM4E | |
| SCHEMBL7413587 | 0.69 | CA1 (0.57) | HTR6HDAC1HDAC6PTGDR2 | |
| SCHEMBL1879444 | 0.67 | HTR6 (0.51) | HTR6HDAC1HDAC6PTGDR2 | |
| SCHEMBL7408166 | 0.67 | HTR6 (0.59) | HTR6HRH1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4257952-A | PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES | STERLING DRUG INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4172834-A | ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS | STERLING DRUG INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4062864-A | ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3959309-A | ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1976-05-25 | — | — | US | disclosed |