SCHEMBL7413587

SCHEMBL7413587

OC1CCc2c(c3ccccc3n2Cc2ccc(Cl)cc2)C1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.57
CA2 P00918 3/20 0.57
DRD3 P35462 2/20 0.53
DRD2 P14416 1/20 0.53
HTR6 P50406 1/20 0.51
TBXA2R P21731 1/20 0.51
PTGDR Q13258 1/20 0.51
HDAC10 Q969S8 3/20 0.47
HDAC6 Q9UBN7 3/20 0.47
HDAC1 Q13547 2/20 0.47
CHRM2 P08172 1/20 0.46
HTR1A P08908 1/20 0.46
ADRA2A P08913 1/20 0.46
CHRM1 P11229 1/20 0.46
DRD1 P21728 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
ADRA1A P35348 1/20 0.46
OPRM1 P35372 1/20 0.46
SLC6A3 Q01959 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7411294 0.91 DRD3 (0.58) CA1CA2DRD3DRD2HTR6
SCHEMBL7407081 0.85 CA1 (0.54) CA1CA2DRD3HTR6TBXA2R
SCHEMBL7415530 0.78 TBXA2R (0.50) CA1CA2TBXA2RPTGDRHDAC10
SCHEMBL8387964 0.76 PTGDR2 (0.58) CA1CA2DRD3HTR6HDAC10
SCHEMBL7411175 0.76 HTR6 (0.57) CA1CA2DRD3HTR6TBXA2R
SCHEMBL7408166 0.76 HTR6 (0.59) CA1CA2DRD3HTR6CHRM2
SCHEMBL7410175 0.75 DRD2 (0.58) DRD3DRD2HTR6TBXA2RPTGDR
SCHEMBL3716403 0.73 CHRM2 (0.83) CA1CA2DRD3HTR6HDAC10
SCHEMBL8390473 0.73 TBXA2R (0.52) CA1CA2DRD3HTR6TBXA2R
SCHEMBL7410052 0.73 DRD2 (0.65) DRD3DRD2HTR6TBXA2RPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4062864-A ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1977-12-13 US claimed
US-4257952-A PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES STERLING DRUG INC. (US) 1981-03-24 US disclosed
US-4172834-A ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS STERLING DRUG INC. (US) 1979-10-30 US disclosed
US-4062864-A ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1977-12-13 US disclosed
US-3959309-A ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1976-05-25 US disclosed