Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 12/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740843 | 1.00 | CHRM1 (0.50) | CHRM1HRH1ADORA2ANPY1RTLR8 | |
| SCHEMBL763181 | 0.91 | TLR8 (0.51) | CHRM1HRH1ADORA2ANPY1RTLR8 | |
| SCHEMBL741172 | 0.88 | CHRM1 (0.50) | CHRM1HRH1NPY1RRENTP53 | |
| SCHEMBL741173 | 0.88 | CHRM1 (0.50) | CHRM1HRH1NPY1RRENTP53 | |
| SCHEMBL739842 | 0.83 | HRH1 (0.70) | CHRM1HRH1NPY1RREN | |
| SCHEMBL739843 | 0.83 | HRH1 (0.70) | CHRM1HRH1NPY1RREN | |
| SCHEMBL7045696 | 0.82 | CHRM1 (0.48) | CHRM1HRH1ADORA2ANPY1RREN | |
| Piperidine SCHEMBL742276 | 0.81 | HRH1 (0.67) | CHRM1HRH1NPY1RREN | |
| SCHEMBL740741 | 0.78 | HRH1 (0.54) | CHRM1HRH1RENTP53MAPT | |
| SCHEMBL742773 | 0.78 | HRH1 (0.54) | CHRM1HRH1RENTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |