Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465219 | 0.98 | AKR1C4 (0.38) | KDM4EHTTATMAKR1C4AKR1C3 | |
| SCHEMBL7420663 | 0.83 | MEN1 (0.45) | KDM4EHTTATMALDH1A1 | |
| SCHEMBL2465485 | 0.81 | PARP1 (0.38) | KDM4EHTTATMFFAR4ALDH1A1 | |
| SCHEMBL2432528 | 0.79 | FFAR4 (0.49) | AKR1C4AKR1C3AKR1C2AKR1C1FFAR4 | |
| Hydrochloric Acid SCHEMBL7626508 | 0.78 | FFAR4 (0.48) | AKR1C4AKR1C3AKR1C2AKR1C1FFAR4 | |
| SCHEMBL7416197 | 0.78 | HTR3A (0.35) | — | |
| SCHEMBL7424251 | 0.77 | FFAR4 (0.35) | KDM4EAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7413765 | 0.76 | FFAR4 (0.42) | KDM4EHTTATMFFAR4ALDH1A1 | |
| SCHEMBL7325572 | 0.74 | FFAR4 (0.36) | AKR1C4AKR1C3AKR1C2AKR1C1FFAR4 | |
| SCHEMBL9204313 | 0.74 | FFAR4 (0.39) | AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991016888-A1 | SPIRO[BENZOFURANCYCLOALKANE]CARBOXAMIDES AS 5HT3 ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-11-14 | — | — | WO | disclosed |