Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412441 | 0.89 | SRC (0.44) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL7413021 | 0.89 | KDM4E (0.45) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7411367 | 0.86 | KDM4E (0.44) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7407974 | 0.86 | KDM4E (0.41) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL4954775 | 0.86 | HPGD (0.53) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7411565 | 0.85 | KDM4E (0.48) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL30417631 | 0.76 | KDM4E (0.53) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7415364 | 0.74 | KDM4E (0.46) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7412091 | 0.74 | GAA (0.49) | KDM4ELMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL7411167 | 0.73 | PTGDR2 (0.46) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |