Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411565 | 0.89 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7412091 | 0.86 | GAA (0.49) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7413021 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7411167 | 0.78 | PTGDR2 (0.46) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL7407974 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL3920169 | 0.74 | TP53 (0.45) | KDM4EALDH1A1GAAMAPTMEN1 | |
| SCHEMBL7408771 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7412441 | 0.71 | SRC (0.44) | KDM4EALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL4842002 | 0.70 | TSPO (0.62) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7411367 | 0.69 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |