Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412091 | 0.89 | GAA (0.49) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7415364 | 0.89 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7408771 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7413021 | 0.75 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7412441 | 0.75 | SRC (0.44) | KDM4EALDH1A1MAPTTSHRPOLB | |
| SCHEMBL5786270 | 0.73 | POLB (0.44) | KDM4EALDH1A1GAAPOLBLMNA | |
| SCHEMBL7411367 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL4954775 | 0.73 | HPGD (0.53) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7407974 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL15420903 | 0.70 | HTR3A (0.58) | KDM4EGAATSHRPOLBHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934319-B1 | 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS | SANOFI SYNTHELABO (FR) | 2002-06-05 | — | — | EP | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |