Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281786 | 0.82 | PDE4B (0.47) | PDE4APDE4DPDE4BPDE4CKMT2A | |
| SCHEMBL2490787 | 0.76 | KDM4E (0.45) | PDE4APDE4DPDE4BPDE4CKMT2A | |
| SCHEMBL31134292 | 0.70 | PDE4B (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL9376230 | 0.70 | PDE4B (0.47) | PDE4APDE4DPDE4BPDE4CMAPT | |
| SCHEMBL7280434 | 0.69 | PDE5A (0.45) | PDE4APDE4DPDE4BPDE4CKMT2A | |
| SCHEMBL3401123 | 0.68 | KMT2A (0.47) | PDE4APDE4DPDE4BPDE4CKMT2A | |
| SCHEMBL7696540 | 0.68 | PDE4A (0.72) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2354338 | 0.68 | CARM1 (0.51) | EPHX2 | |
| SCHEMBL5132385 | 0.68 | PDE4D (0.42) | PDE4APDE4DPDE4BPDE4CKMT2A | |
| SCHEMBL3407610 | 0.68 | THRA (0.43) | PDE4APDE4DPDE4BPDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796093-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-05-13 | — | — | EP | disclosed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | disclosed |