Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979380 | 0.80 | LMNA (0.56) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL565078 | 0.80 | LMNA (0.56) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL518141 | 0.80 | LMNA (0.56) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL150334 | 0.79 | LMNA (0.77) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL5590508 | 0.78 | LMNA (0.54) | LMNAALDH1A1TSHRTDP1NT5E | |
| Formaldehyde SCHEMBL28763457 | 0.76 | LMNA (0.65) | LMNAALDH1A1TSHRTDP1NT5E | |
| Formaldehyde SCHEMBL27960582 | 0.76 | LMNA (0.65) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL27697112 | 0.76 | LMNA (0.52) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL28425275 | 0.76 | LMNA (0.52) | LMNAALDH1A1TSHRTDP1NT5E | |
| SCHEMBL1892147 | 0.76 | TSHR (0.55) | LMNAALDH1A1TSHRTDP1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4891370-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4847247-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| US-4797396-A | INHIBITION OF ELASTASE, ANTIBIOTICS | MERCK & CO., INC. (US) | 1989-01-10 | — | — | US | disclosed |
| US-4717722-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1988-01-05 | — | — | US | disclosed |
| US-4711886-A | β-lactam derivatives as anti-inflammatory and antidegenerative agents | MERCK & CO., INC. (US) | 1987-12-08 | — | — | US | disclosed |
| US-4623645-A | ELASTASE INHIBITORS | MERCK & CO., INC. (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0170192-A1 | Penicillin derivatives as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1986-02-05 | — | — | EP | disclosed |
| US-4547371-A | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents | MERCK & CO., INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4390693-A | BACTERICIDE | MERCK & CO., INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4386089-A | BACTERICIDES, GROWTH PROMOTERS | BAYER AKTIENGESELLSCHAFT (DE) | 1983-05-31 | — | — | US | disclosed |
| US-4297488-A | 7-α-Methoxy cephalosporins | MERCK & CO., INC. (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0004956-B1 | BETA-LACTAM ANTIBIOTICS, PROCESS FOR THEIR PREPARATION, FODDER ADDITIVES, DRUGS AND PROCESS FOR THEIR PREPARATION | BAYER AG (DE) | 1981-10-14 | — | — | EP | disclosed |
| US-4255423-A | BACTERICIDES | MERCK & CO., INC. (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0004956-A1 | Beta-lactam antibiotics, process for their preparation, fodder additives, drugs and process for their preparation | BAYER AG (DE) | 1979-10-31 | — | — | EP | disclosed |
| US-4154845-A | ANTIBIOTIC, BACTERICIDE | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4086423-A | CEPHALOSPORINS, CYCLOADDITION OF GLYCINE DERIVATIVE TO THIAZINE COMPOUND | MERCK & CO., INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4071529-A | Derivatives of 6-aminopenicillanic acid | MERCK & CO., INC. (US) | 1978-01-31 | — | — | US | disclosed |
| US-4064344-A | ANTIBIOTIC | MERCK & CO., INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4035359-A | 6α, β-Substituted penicillin derivatives | MERCK & CO., INC. (US) | 1977-07-12 | — | — | US | disclosed |
| US-3974151-A | Cephalosporin compounds | MERCK & CO., INC. (US) | 1976-08-10 | — | — | US | disclosed |