Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11453895 | 0.84 | GRIA4 (0.50) | ALDH1A1MAPTL3MBTL1GRIA4DAO | |
| SCHEMBL28880915 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTL3MBTL1GRIA4DAO | |
| SCHEMBL27652849 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPTL3MBTL1GRIA4DAO | |
| SCHEMBL8030767 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPTL3MBTL1GRIA4DAO | |
| SCHEMBL28766105 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MAPTL3MBTL1GRIA4DAO | |
| SCHEMBL30423174 | 0.78 | PTGER1 (0.42) | KMT2A | |
| SCHEMBL12856701 | 0.78 | PTPRC (0.56) | ALDH1A1MAPTL3MBTL1GRIA4PTPRC | |
| SCHEMBL10436027 | 0.78 | GRM2 (0.47) | ALDH1A1GRM2PPARGMEN1KMT2A | |
| SCHEMBL15546386 | 0.78 | PTGS1 (0.44) | MAPTMEN1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL22294669 | 0.78 | CA12 (0.38) | PTPN1GRM2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979226-A1 | ISOXAZOLE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998047880-A1 | ISOXAZOLE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-10-29 | — | — | WO | disclosed |
| US-4968702-A | ANTIARTHRITIC, INHIBITORS OF PROGRESSIVE JOINT DETERIORATION, IMMUNOSUPPRESSANT | AMERICAN CYANAMID COMPANY (US) | 1990-11-06 | — | — | US | disclosed |