Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.51 |
| ▸ | MMP9 | P14780 | 17/20 | 0.51 |
| ▸ | MMP1 | P03956 | 17/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348654 | 0.91 | MMP9 (0.43) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7357288 | 0.88 | MMP9 (0.41) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7353676 | 0.88 | MMP1 (0.66) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7345984 | 0.86 | MMP13 (0.44) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7347280 | 0.84 | MMP13 (0.42) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7355972 | 0.83 | MMP1 (0.66) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7416424 | 0.82 | MMP13 (0.44) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7352386 | 0.82 | MMP1 (0.52) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7350596 | 0.81 | MMP1 (0.54) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7349184 | 0.81 | MMP1 (0.49) | MMP13MMP9MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054858-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-29 | — | — | EP | disclosed |
| EP-0973512-A1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999042436-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-08-26 | — | — | WO | disclosed |
| WO-1998037877-A1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-09-03 | — | — | WO | disclosed |