Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019657 | 0.88 | TLR8 (0.44) | TLR8MTNR1ATNFHIF1AKDM4E | |
| SCHEMBL7016987 | 0.83 | TLR8 (0.49) | TLR8MTNR1AHIF1AKDM4ERAB9A | |
| SCHEMBL7017097 | 0.81 | TLR8 (0.44) | TLR8MTNR1AHIF1AKDM4ERAB9A | |
| SCHEMBL11303560 | 0.74 | LMNA (0.54) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16650194 | 0.74 | KDM4E (0.40) | TLR8ABCG2KDM4ERAB9AALDH1A1 | |
| SCHEMBL16651640 | 0.72 | TRPA1 (0.40) | TLR8MTNR1AKDM4ERAB9AALDH1A1 | |
| SCHEMBL7019368 | 0.72 | CCR1 (0.37) | TLR8MTNR1ATNFKDM4ERAB9A | |
| SCHEMBL16651306 | 0.72 | ALDH1A1 (0.35) | TLR8MTNR1ATNFKDM4ERAB9A | |
| SCHEMBL7018733 | 0.72 | MKNK1 (0.35) | TLR8MTNR1AKDM4ERAB9AALDH1A1 | |
| SCHEMBL7013224 | 0.71 | LMNA (0.57) | MTNR1AKDM4ERAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |