Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13588768 | 0.81 | ALDH1A1 (0.50) | FDPSALDH1A1GAAPOLBNPC1 | |
| SCHEMBL3890657 | 0.81 | POLB (0.57) | ALDH1A1GAAPOLBNPC1PKM | |
| SCHEMBL3709832 | 0.78 | GAA (0.55) | DPP8DPP9DPP7DPP4ALDH1A1 | |
| SCHEMBL7359301 | 0.73 | DPP8 (0.45) | DPP8DPP9DPP7DPP4ALDH1A1 | |
| SCHEMBL7359295 | 0.73 | DPP8 (0.45) | DPP8DPP9DPP7DPP4ALDH1A1 | |
| SCHEMBL2857962 | 0.73 | GAA (0.55) | FDPSALDH1A1GAANPC1PKM | |
| SCHEMBL13589538 | 0.73 | GAA (0.55) | FDPSALDH1A1GAANPC1PKM | |
| SCHEMBL22338149 | 0.73 | GAA (0.51) | FDPSALDH1A1GAAPOLBNPC1 | |
| SCHEMBL9722609 | 0.72 | GAA (0.58) | FDPSALDH1A1GAANPC1PKM | |
| SCHEMBL534155 | 0.71 | GAA (0.56) | FDPSALDH1A1GAANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349570-A1 | RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE | THE UPJOHN COMPANY (US) | 1990-01-10 | — | — | EP | disclosed |
| WO-1988007053-A1 | RENIN INHIBITORS CONTAINING A CYCLOPROPYL AMINO ACID AND/OR A CYCLOALKYL TRANSITION-STATE ANALOGUE | THE UPJOHN COMPANY (US) | 1988-09-22 | — | — | WO | disclosed |