Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350189 | 0.84 | SRC (0.34) | HTR6L3MBTL1GABRG2GABRB3GABRA5 | |
| SCHEMBL5414470 | 0.83 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1POLBHTR6L3MBTL1 | |
| SCHEMBL1162095 | 0.77 | L3MBTL1 (0.41) | HSP90AA1HSP90AB1POLBHTR6L3MBTL1 | |
| SCHEMBL15208125 | 0.76 | L3MBTL1 (0.36) | HSP90AA1HSP90AB1HTR6L3MBTL1ALDH1A1 | |
| SCHEMBL832511 | 0.73 | RIPK1 (0.42) | HSP90AA1HSP90AB1HTR6L3MBTL1ALDH1A1 | |
| SCHEMBL20916611 | 0.73 | PIK3CD (0.37) | HSP90AA1HSP90AB1HTR6L3MBTL1ALDH1A1 | |
| SCHEMBL7350939 | 0.72 | L3MBTL1 (0.40) | HSP90AA1HSP90AB1HTR6L3MBTL1ALDH1A1 | |
| SCHEMBL15208581 | 0.72 | ALDH1A1 (0.36) | HTR6L3MBTL1LMNAALDH1A1MAPK1 | |
| SCHEMBL15392448 | 0.72 | BCHE (0.38) | HSP90AA1HSP90AB1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL6142331 | 0.71 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1HTR6L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |