SCHEMBL7410362

SCHEMBL7410362

CC(C)(C)OC(=O)[C@@]1(COc2cncc([N+](=O)[O-])c2)CCCN1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.32
SLC6A2 P23975 2/20 0.32
SLC6A4 P31645 2/20 0.32
SLC6A3 Q01959 2/20 0.32
LMNA P02545 2/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
CHRNB1 P11230 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNB3 Q05901 1/20 0.31
MET P08581 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2300520 0.80 DGAT1 (0.37) CHRNB2
SCHEMBL2185911 0.80 DGAT1 (0.37) CHRNB2
SCHEMBL7409382 0.77 CYP2D6 (0.34) CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL7413163 0.75 NPC1 (0.35) CYP2D6SLC6A2SLC6A4SLC6A3MAPT
SCHEMBL6266474 0.71 MAPT (0.44) MAPT
SCHEMBL3357488 0.70 SLC6A4 (0.44) CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL7413347 0.68 CHRNB2 (0.45) ALDH1A1CHRNB2CHRNB4CHRNA3
SCHEMBL7415129 0.68 CHRNB2 (0.40) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL2185728 0.68 BACE1 (0.34) CHRNB2
SCHEMBL7483954 0.68 CHRNA3 (0.45) LMNAALDH1A1MAPTCHRNB1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed
EP-0846114-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-06-10 EP disclosed
WO-1996040682-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1996-12-19 WO disclosed