Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413449 | 0.87 | ADORA3 (0.56) | ADORA3ADORA1NR1H3MEN1KMT2A | |
| SCHEMBL7415475 | 0.84 | MAPT (0.49) | ADORA3MEN1KMT2AATMALDH1A1 | |
| SCHEMBL7407990 | 0.82 | MAPK14 (0.53) | ADORA3MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7412697 | 0.82 | ADORA3 (0.51) | ADORA3MEN1KMT2AATMALDH1A1 | |
| SCHEMBL7409290 | 0.79 | MAPK14 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7413902 | 0.77 | ADORA3 (0.50) | ADORA3ADORA1MEN1KMT2AATM | |
| SCHEMBL7409538 | 0.77 | ADORA3 (0.50) | ADORA3ADORA1MEN1KMT2AATM | |
| SCHEMBL7415160 | 0.76 | ADORA3 (0.54) | ADORA3ADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL7415495 | 0.74 | KDM4E (0.40) | ADORA3ADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL7415108 | 0.73 | CASP3 (0.55) | ADORA3MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | claimed |
| US-5908932-A | Certain pyrroloquinolinones; a new class of GABA brain receptor | NEUROGEN CORPORATION (US) | 1999-06-01 | — | — | US | disclosed |
| US-5604235-A | DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, BENZODIAZEPINE OVERDOSE; ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION (US) | 1997-02-18 | — | — | US | disclosed |
| WO-1994026741-A1 | CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |