Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415475 | 0.82 | MAPT (0.49) | KDM4EALDH1A1PARP1TNKSTNKS2 | |
| SCHEMBL7409290 | 0.77 | MAPK14 (0.53) | KDM4EALDH1A1PARP1TNKSTNKS2 | |
| SCHEMBL7412697 | 0.77 | ADORA3 (0.51) | KDM4EALDH1A1PARP1TNKSTNKS2 | |
| SCHEMBL7407990 | 0.77 | MAPK14 (0.53) | KDM4EALDH1A1PARP1TNKSTNKS2 | |
| SCHEMBL7412708 | 0.76 | CDK5 (0.43) | KDM4EALDH1A1PARP1TNKSTNKS2 | |
| SCHEMBL7414758 | 0.74 | HTT (0.54) | KDM4EPARP1HSD17B10CDK5CDK5R1 | |
| SCHEMBL7415160 | 0.74 | ADORA3 (0.54) | ALDH1A1MEN1KMT2AHSD17B10MAPT | |
| SCHEMBL7418663 | 0.74 | ADORA3 (0.54) | KDM4EALDH1A1PARP1TNKSTNKS2 | |
| SCHEMBL7410394 | 0.74 | ADORA3 (0.54) | KDM4EALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL7413449 | 0.72 | ADORA3 (0.56) | KDM4EALDH1A1MEN1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994026741-A1 | CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | claimed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | claimed |
| US-5908932-A | Certain pyrroloquinolinones; a new class of GABA brain receptor | NEUROGEN CORPORATION (US) | 1999-06-01 | — | — | US | disclosed |
| US-5604235-A | DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, BENZODIAZEPINE OVERDOSE; ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION (US) | 1997-02-18 | — | — | US | disclosed |
| WO-1994026741-A1 | CERTAIN PYRROLOQUINOLINONES; A NEW CLASS OF GABE BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |