Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540221 | 0.88 | TACR1 (0.48) | CMA1ACE | |
| SCHEMBL8662695 | 0.87 | ELANE (0.45) | ELANEXIAPMLXCMA1 | |
| SCHEMBL7400531 | 0.83 | ELANE (0.47) | ELANEXIAPMLX | |
| SCHEMBL7874280 | 0.83 | EPHA2 (0.43) | ACE | |
| SCHEMBL6057548 | 0.82 | XIAP (0.46) | ELANEXIAPMLXCMA1ACE | |
| SCHEMBL5494650 | 0.82 | ELANE (0.40) | ELANEXIAPMLXCMA1 | |
| SCHEMBL10895690 | 0.81 | ELANE (0.42) | ELANECMA1 | |
| SCHEMBL8333459 | 0.80 | PSMB9 (0.47) | XIAP | |
| SCHEMBL1289940 | 0.79 | CMA1 (0.54) | ELANEXIAPCMA1ACE | |
| SCHEMBL8660922 | 0.77 | ELANE (0.39) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189901-A1 | OXAZAHETEROCYCLES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000073302-A1 | OXAZAHETEROCYCLES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-12-07 | — | — | WO | disclosed |