SCHEMBL5494650

SCHEMBL5494650

CON1C(=O)CCC(=O)[C@]1(C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N([N+]=O)c1ccccc1)C(C)C

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ELANE P08246 16/20 0.40
CMA1 P23946 2/20 0.37
XIAP P98170 1/20 0.36
MLX Q9UH92 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8660922 0.91 ELANE (0.39) ELANE
SCHEMBL2289363 0.85 ELANE (0.42) ELANECMA1XIAPMLX
SCHEMBL8665933 0.85 EP300 (0.37) ELANE
SCHEMBL10895690 0.83 ELANE (0.42) ELANECMA1
SCHEMBL8662040 0.82 ELANE (0.40) ELANECMA1XIAPMLX
SCHEMBL7410732 0.82 ELANE (0.43) ELANECMA1XIAPMLX
SCHEMBL847832 0.81 CMA1 (0.49) CMA1XIAP
SCHEMBL228960 0.81 ELANE (0.38) ELANECMA1XIAPMLX
SCHEMBL5487413 0.81 ELANE (0.38) ELANECMA1XIAPMLX
SCHEMBL3276266 0.79 ELANE (0.42) ELANECMA1XIAPMLX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3071688-A1 MICROSPHERE-BASED DELIVERY AND EX VIVO MANIPULATION OF DENDRITIC CELLS FOR AUTOIMMUNE THERAPIES University of Pittsburgh - Of the Commonwealth System of Higher Education (US) 2016-09-28 EP disclosed
WO-2015074057-A1 MICROSPHERE-BASED DELIVERY AND EX VIVO MANIPULATION OF DENDRITIC CELLS FOR AUTOIMMUNE THERAPIES UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2015-05-21 WO disclosed
EP-2673381-A2 BIOPROBES AND METHODS OF USE THEREOF The Governing Council Of The University Of Toronto (CA) 2013-12-18 EP disclosed
WO-2012109157-A2 BIOPROBES AND METHODS OF USE THEREOF THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2012-08-16 WO disclosed
EP-1805220-A1 METHOD FOR TREATING TUMORS USING ANTI-OSTEOPONTIN ANTIBODIES GENENTECH, INC. (US) 2007-07-11 EP disclosed
WO-2006043954-A1 METHOD FOR TREATING TUMORS USING ANTI-OSTEOPONTIN ANTIBODIES GENENTECH, INC. (US) 2006-04-27 WO disclosed
US-6743591-B1 FOR HIGHER ACCURACY USING AN AUTOMATED COUNTER ARKRAY, INC. (JP) 2004-06-01 US disclosed
WO-2003063803-A1 BIOACTIVE BOTANICAL COSMETIC INGREDIENTS AND PROCESSES FOR THEIR PRODUCTION INTEGRATED BOTANICAL TECHNOLOGIES, LLC (US) 2003-08-07 WO disclosed
WO-2000035905-A1 INHIBITORS OF β-LACTAMASES AND USES THEREFOR NORTHWESTERN UNIVERSITY (US) 2000-06-22 WO disclosed
EP-0114777-B1 EXPRESSION VEHICLES AND THEIR USE IN THE PREPARATION OF A PROTEIN HAVING HUMAN ALPHA-ANTITRYPSIN ACTIVITY TRANSGENE S.A. (FR) 1990-08-01 EP disclosed
US-4551279-A Protease inhibitors G. D. SEARLE & CO. (US) 1985-11-05 US disclosed
EP-0156100-A2 3-Substituted hydroxypentanedioic acids, -hemiesters or -anhydrides G.D. Searle & Co. (US) 1985-10-02 EP disclosed
EP-0148752-A2 Protease inhibitors G.D. Searle & Co. (US) 1985-07-17 EP disclosed
US-4501895-A ELASTIN DEGRADATION INHIBITION G.D. SEARLE & CO. (US) 1985-02-26 US disclosed
US-4499295-A Protease inhibitors G. D. SEARLE & CO. (US) 1985-02-12 US disclosed
EP-0126372-A1 Halogenated protease inhibitors G.D. Searle & Co. (US) 1984-11-28 EP disclosed
EP-0124905-A1 Protease inhibitors G.D. Searle & Co. (US) 1984-11-14 EP disclosed
US-4469885-A Halogenated protease inhibitors G. D. SEARLE & CO. (US) 1984-09-04 US disclosed
WO-1984002918-A1 NEW EXPRESSION VECTORS AND APPLICATION THEREOF TO THE PREPARATION OF A PROTEIN HAVING THE ACTIVITY OF HUMAN ANTITRYPSIN-alpha1 TRANSGENE SA (FR) 1984-08-02 WO disclosed
EP-0114777-A2 Expression vehicles and their use in the preparation of a protein having human alpha-antitrypsin activity TRANSGENE S.A. (FR) 1984-08-01 EP disclosed