Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414043 | 0.91 | HTR6 (0.47) | HTR6MAPTTP53LMNA | |
| SCHEMBL7402536 | 0.86 | HTR1D (0.57) | HTR2AHTR6HTR7MAPTTP53 | |
| SCHEMBL7463173 | 0.85 | CGAS (0.38) | HTR2AHTR6HTR1AHTR7MAPT | |
| SCHEMBL3800074 | 0.85 | MAPT (0.42) | HTR6MAPTTP53LMNA | |
| SCHEMBL7403630 | 0.84 | CYP19A1 (0.50) | HTR6MAPTTP53 | |
| SCHEMBL7410085 | 0.84 | KMT2A (0.49) | HTR6MAPTTP53LMNA | |
| SCHEMBL7407214 | 0.83 | MAPT (0.40) | HTR6MAPTTP53LMNA | |
| SCHEMBL7415797 | 0.77 | CYP2D6 (0.40) | HTR6MAPTTP53LMNA | |
| SCHEMBL23657201 | 0.72 | KMT2A (0.64) | HTR2AHTR1AMAPTHTR2CSIRT1 | |
| SCHEMBL4905222 | 0.72 | VPS4B (0.47) | HTR2AHTR6HTR1AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4257952-A | PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES | STERLING DRUG INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4172834-A | ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS | STERLING DRUG INC. (US) | 1979-10-30 | — | — | US | disclosed |
| US-4062864-A | ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3959309-A | ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE | STERLING DRUG INC. (US) | 1976-05-25 | — | — | US | disclosed |