Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460237 | 0.89 | NR1H4 (0.47) | KDM4ENPC1RAB9APLAUNR1H4 | |
| SCHEMBL7407271 | 0.87 | F10 (0.51) | ALDH1A1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL7411398 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KDM4EALOX12NPC1RAB9A | |
| SCHEMBL7411445 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KDM4EALOX12NPC1RAB9A | |
| SCHEMBL7407140 | 0.86 | PLAU (0.50) | ALDH1A1KDM4EPLAUMAPTMEN1 | |
| SCHEMBL8417467 | 0.85 | KMT2A (0.53) | ALDH1A1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL7413373 | 0.85 | CREBBP (0.44) | ALDH1A1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL7409768 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KDM4EALOX12NPC1RAB9A | |
| SCHEMBL7411939 | 0.79 | MEN1 (0.60) | MAPTMEN1KMT2A | |
| SCHEMBL8414166 | 0.77 | CHEK1 (0.51) | ALDH1A1KDM4ERAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999042439-A1 | NOVEL THIOBENZAMIDES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-26 | — | — | WO | claimed |
| WO-1999042439-A1 | NOVEL THIOBENZAMIDES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-08-26 | — | — | WO | disclosed |
| EP-0937711-A1 | Thiobenzamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-08-25 | — | — | EP | disclosed |