Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 6/20 | 0.33 |
| ▸ | MMP3 | P08254 | 3/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 3/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383416 | 0.85 | REN (0.39) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL7383043 | 0.84 | MMP1 (0.34) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL23911882 | 0.80 | CCNA2 (0.35) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL7478743 | 0.78 | MMP2 (0.39) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL7380889 | 0.77 | MEN1 (0.32) | MMP1MMP3BCHEALDH1A1HPGD | |
| SCHEMBL7410645 | 0.77 | MEN1 (0.32) | MMP1MMP3BCHEALDH1A1HPGD | |
| SCHEMBL7380103 | 0.77 | MEN1 (0.32) | MMP1MMP3BCHEALDH1A1HPGD | |
| SCHEMBL19161112 | 0.75 | HPGD (0.37) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL4635116 | 0.75 | MME (0.40) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL7389199 | 0.74 | CCNA2 (0.36) | CCNA2CDK2CCNA1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191150-B1 | METALLOPROTEASE INHIBITOR | GLAXO WELLCOME INC. | 2001-02-20 | — | — | US | disclosed |
| WO-2000012466-A1 | FORMAMIDE COMPOUNDS AS THERAPEUTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |