Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.71 |
| ▸ | SDCBP | O00560 | 4/20 | 0.49 |
| ▸ | SDC2 | P34741 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335896 | 0.83 | REN (1.00) | RENSDCBPSDC2MEN1KMT2A | |
| SCHEMBL7335387 | 0.82 | REN (1.00) | RENSDCBPSDC2MEN1KMT2A | |
| SCHEMBL7331024 | 0.82 | REN (1.00) | RENSDCBPSDC2MEN1KMT2A | |
| SCHEMBL7332395 | 0.77 | REN (0.77) | RENSDCBPSDC2MEN1KMT2A | |
| SCHEMBL7327232 | 0.77 | REN (1.00) | RENSDCBPSDC2MEN1KMT2A | |
| SCHEMBL7386223 | 0.70 | REN (1.00) | REN | |
| SCHEMBL7331414 | 0.69 | REN (1.00) | REN | |
| SCHEMBL12516680 | 0.68 | SDCBP (1.00) | SDCBPSDC2MEN1KMT2AMAPT | |
| SCHEMBL7325745 | 0.67 | REN (0.73) | REN | |
| SCHEMBL1107311 | 0.66 | ALOX15 (0.51) | RENSDCBPSDC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075451-A | Pyrrolimidazolones useful as renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |