Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | CTSE | P14091 | 1/20 | 0.45 |
| ▸ | PGC | P20142 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 10/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916903 | 1.00 | CTSD (0.45) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL7411853 | 1.00 | CTSD (0.45) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6449190 | 0.84 | CTSD (0.61) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL7408240 | 0.84 | CTSD (0.61) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6449191 | 0.84 | CTSD (0.61) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL7374902 | 0.84 | REN (0.43) | RENKLK5ATMKMT2A | |
| SCHEMBL7371572 | 0.84 | REN (0.43) | RENKLK5ATMKMT2A | |
| SCHEMBL6444998 | 0.83 | CTSD (0.43) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6445002 | 0.83 | CTSD (0.43) | CTSDCTSEPGCRENKLK5 | |
| SCHEMBL6442709 | 0.78 | CTSD (0.51) | CTSDCTSEPGCRENKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670497-A | RETROVIRAL PROTEASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1997-09-23 | — | — | US | disclosed |
| EP-0708760-A1 | CYCLIC HYDRAZINE COMPOUNDS | Novartis AG (CH) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002582-A1 | CYCLIC HYDRAZINE COMPOUNDS | CIBA-GEIGY AG (CH) | 1995-01-26 | — | — | WO | disclosed |