Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 11/20 | 0.47 |
| ▸ | ACE | P12821 | 11/20 | 0.47 |
| ▸ | CPA1 | P15085 | 9/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412188 | 1.00 | MME (0.47) | MMEACE2ACECPA1ITGB3 | |
| SCHEMBL7413773 | 0.91 | PTPN5 (0.46) | MMEACE2ACECPA1PTPN5 | |
| SCHEMBL7413785 | 0.91 | PTPN5 (0.46) | MMEACE2ACECPA1PTPN5 | |
| SCHEMBL7407171 | 0.88 | MME (0.50) | MMEACE2ACECPA1 | |
| SCHEMBL7407179 | 0.88 | MME (0.50) | MMEACE2ACECPA1 | |
| SCHEMBL7308615 | 0.85 | MMEL1 (0.53) | MMEACE | |
| SCHEMBL7415667 | 0.81 | MME (0.45) | MMEACE2ACECPA1GPR34 | |
| SCHEMBL7415653 | 0.81 | MME (0.45) | MMEACE2ACECPA1GPR34 | |
| SCHEMBL7466179 | 0.81 | FPR2 (0.45) | MMEACE2ACECPA1 | |
| SCHEMBL7466201 | 0.81 | FPR2 (0.45) | MMEACE2ACECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| US-5250522-A | Neutral endopeptidase inhibitors; cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |