SCHEMBL7412191

SCHEMBL7412191

CC(C)=C(c1ccc(C(=O)O)cc1)c1ccc2c(c1)C(C)(C)CCC2(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 14/20 1.00
RXRB P28702 8/20 1.00
RARB P10826 13/20 0.72
RARG P13631 12/20 0.72
RXRG P48443 6/20 0.72
RARA P10276 9/20 0.68
CYP26A1 O43174 4/20 0.66
CYP3A4 P08684 3/20 0.66
ALDH1A1 P00352 2/20 0.66
CYP1A2 P05177 2/20 0.66
CYP2C19 P33261 2/20 0.66
KDM4E B2RXH2 1/20 0.66
NPC1 O15118 1/20 0.66
GMNN O75496 1/20 0.66
USP2 O75604 1/20 0.66
LMNA P02545 1/20 0.66
TP53 P04637 1/20 0.66
POLB P06746 1/20 0.66
CYP2D6 P10635 1/20 0.66
NFKB1 P19838 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29827631 0.87 RARB (0.81) RXRARXRBRARBRARGRXRG
SCHEMBL846110 0.87 RARB (0.81) RXRARXRBRARBRARGRXRG
Hydrochloric Acid SCHEMBL9120757 0.85 RARB (0.78) RXRARXRBRARBRARGRXRG
SCHEMBL9319026 0.84 RXRA (0.77) RXRARXRBRARBRARGRXRG
SCHEMBL10355871 0.84 RXRA (1.00) RXRARXRBRARBRARGRXRG
SCHEMBL3454328 0.84 RXRA (1.00) RXRARXRBRARBRARGRXRG
SCHEMBL7421190 0.84 RXRA (0.72) RXRARXRBRARBRARGRXRG
Hydrazine SCHEMBL9430381 0.83 RARB (0.76) RXRARXRBRARBRARGRXRG
SCHEMBL8610553 0.82 RXRA (0.70) RXRARXRBRARBRARGRXRG
SCHEMBL21082224 0.82 RXRA (0.69) RXRARXRBRARBRARGRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12533309-B2 Minoxidil adjuvant therapies CARING BRANDS, INC. (US) 2026-01-27 US disclosed
US-12527729-B2 Minoxidil adjuvant therapies CARING BRANDS, INC. (US) 2026-01-20 US disclosed
US-20250360128-A1 MINOXIDIL ADJUVANT THERAPIES JUPITER WELLNESS INC (US) 2025-11-27 US disclosed
US-20240299329-A1 PRECURSOR COMPOUNDS FOR PROVIDING RETINOIDS OF THE VATAMIN A5 PATHWAY AND USES THEREOF UNIV OF DEBRECEN (HU) 2024-09-12 US disclosed
US-12029715-B2 Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof UNIVERSITY OF DEBRECEN (HU) 2024-07-09 US disclosed
US-20240009101-A1 MINOXIDIL ADJUVANT THERAPIES Jupiter Wellness, Inc. (US) 2024-01-11 US disclosed
US-20230404886-A1 MINOXIDIL ADJUVANT THERAPIES Jupiter Wellness, Inc. (US) 2023-12-21 US disclosed
CN-117243839-A Minoxidil adjuvant therapy 应用生物学股份有限公司 2023-12-19 CN disclosed
US-11766392-B2 Minoxidil adjuvant therapies Jupiter Wellness, Inc. (US) 2023-09-26 US disclosed
EP-3495349-B1 (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2023-06-28 EP disclosed
US-6083973-A ADMINISTERING TO THE MAMMAL RETINOIC ACID RECEPTOR ANTAGONIST OR PRODRUG TO PREVENT MUCIN PRODUCTION SYNTEX (U.S.A.) INC. (US) 2000-07-04 US disclosed
WO-1999045915-A1 USE OF ALPHA-RAR ANTAGONISTS FOR INHIBITION OF MUCIN SECRETION F. HOFFMANN-LA ROCHE AG (CH) 1999-09-16 WO disclosed
US-5650279-A ISOLATED POLYNUCLEOTIDE WHICH SPECIFICALLY BINDS TAZAROTENE INDUCIBLE GENE ALLERGAN, INC. (US) 1997-07-22 US disclosed
US-5552271-A SCREENING FOR SUBSTANCES WHICH INDUCE FORMATION OF RETINOID XRECEPTOR HOMODIMERS LA JOLLA CANCER RESEARCH FOUNDATION (US) 1996-09-03 US disclosed
WO-1996023080-A1 GENE SEQUENCE INDUCED IN SKIN BY RETINOIDS ALLERGAN (US) 1996-08-01 WO disclosed
WO-1995033745-A9 NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY 1996-01-18 WO disclosed
WO-1995033745-A2 NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY SRI INTERNATIONAL (US) 1995-12-14 WO disclosed
US-5466861-A Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors SRI INTERNATIONAL (US) 1995-11-14 US disclosed
EP-0671005-A1 RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION LA JOLLA CANCER RESEARCH FOUNDATION (US) 1995-09-13 EP disclosed
WO-1994012880-A2 RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION LA JOLLA CANCER RESEARCH FOUNDATION (US) 1994-06-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029715-B2 Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof RXRA, RXRG, RARA RXRA 1/4885RXRB 4/4885RARB 6/4885
US-12527729-B2 Minoxidil adjuvant therapies RXRA, RXRB, RXRG RXRA 1/4885RXRB 2/4885RARB 4/4885
US-20240299329-A1 PRECURSOR COMPOUNDS FOR PROVIDING RETINOIDS OF THE VATAMIN A5 PATHWAY AND USES THEREOF RXRA, RARA, RXRG RXRA 1/4885RXRB 4/4885RARB 6/4885
US-12533309-B2 Minoxidil adjuvant therapies RXRG, RXRA, RXRB RXRA 2/4885RXRB 3/4885RARB 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.