Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15361972 | 0.84 | TLR8 (0.54) | KDM4ESMN1; SMN2LMNATLR8NPC1 | |
| SCHEMBL7005281 | 0.84 | TLR8 (0.49) | KDM4ESMN1; SMN2LMNATP53TLR8 | |
| SCHEMBL7004489 | 0.77 | PDE10A (0.52) | KDM4ESMN1; SMN2TP53TLR8NPC1 | |
| SCHEMBL7007754 | 0.77 | NPC1 (0.54) | KDM4ESMN1; SMN2LMNATP53TLR8 | |
| SCHEMBL28653821 | 0.77 | TLR8 (0.60) | KDM4ESMN1; SMN2TLR8NPC1MAPT | |
| SCHEMBL16797438 | 0.76 | KDM4E (1.00) | KDM4ESMN1; SMN2LMNATP53NPC1 | |
| SCHEMBL14085522 | 0.74 | TP53 (0.49) | KDM4ESMN1; SMN2LMNATP53MAPT | |
| SCHEMBL28180362 | 0.72 | MAPT (0.55) | KDM4ESMN1; SMN2LMNATP53TLR8 | |
| SCHEMBL22033267 | 0.72 | TLR8 (0.56) | KDM4ESMN1; SMN2LMNATLR8NPC1 | |
| SCHEMBL7005330 | 0.71 | TLR8 (0.51) | KDM4ESMN1; SMN2TLR8NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | KDM4E 1876/4885SMN1; SMN2 3141/4885LMNA 2937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.