Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374141 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL1778339 | 0.73 | SMN1; SMN2 (0.44) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL11562262 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL4891782 | 0.69 | KDM4E (0.43) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL7417039 | 0.69 | KMT2A (0.38) | ALDH1A1GAAKMT2A | |
| SCHEMBL4353356 | 0.68 | ALDH1A1 (0.46) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL7382372 | 0.68 | RAF1 (0.34) | — | |
| SCHEMBL7379327 | 0.67 | MPO (0.34) | — | |
| SCHEMBL762264 | 0.67 | SMN1; SMN2 (0.43) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL5898267 | 0.67 | SMN1; SMN2 (0.47) | KDM4EALDH1A1GAARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |