Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14759859 | 0.77 | P2RX7 (0.48) | KMT2AMEN1GAAALDH1A1L3MBTL1 | |
| SCHEMBL12500526 | 0.75 | P2RX7 (0.44) | KMT2AMEN1GAAALDH1A1L3MBTL1 | |
| SCHEMBL5196264 | 0.72 | LMNA (0.42) | KMT2AMEN1GAAALDH1A1L3MBTL1 | |
| SCHEMBL7382372 | 0.69 | RAF1 (0.34) | TDP1 | |
| SCHEMBL7414694 | 0.69 | SLC11A2 (0.36) | KMT2AMEN1MAPTTDP1 | |
| SCHEMBL7412860 | 0.69 | KDM4E (0.42) | KMT2AGAAALDH1A1 | |
| SCHEMBL314801 | 0.68 | MEN1 (0.45) | KMT2AMEN1GAAALDH1A1L3MBTL1 | |
| SCHEMBL2172793 | 0.67 | P2RX7 (0.49) | KMT2AMEN1GAAALDH1A1L3MBTL1 | |
| SCHEMBL2972393 | 0.67 | P2RX7 (0.53) | KMT2AMEN1ALDH1A1P2RX7ATM | |
| SCHEMBL10242696 | 0.67 | P2RX7 (0.49) | KMT2AMEN1GAAALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |