Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740270 | 1.00 | KMT2A (0.36) | KMT2AKDM4ECLK1RXFP1HCRTR1 | |
| SCHEMBL738530 | 1.00 | KMT2A (0.36) | KMT2AKDM4ECLK1RXFP1HCRTR1 | |
| SCHEMBL741288 | 0.93 | CFD (0.36) | KMT2AKDM4ECLK1RXFP1HCRTR1 | |
| SCHEMBL741289 | 0.93 | CFD (0.36) | KMT2AKDM4ECLK1RXFP1HCRTR1 | |
| SCHEMBL739350 | 0.89 | KDM4E (0.35) | KMT2AKDM4ECLK1RXFP1HCRTR1 | |
| SCHEMBL739351 | 0.89 | KDM4E (0.35) | KMT2AKDM4ECLK1RXFP1HCRTR1 | |
| SCHEMBL741966 | 0.86 | AKT1 (0.36) | CFDBTKNPY1R | |
| SCHEMBL741986 | 0.86 | SMYD3 (0.35) | KMT2AALDH1A1TSHRCFDBTK | |
| SCHEMBL741987 | 0.86 | SMYD3 (0.35) | KMT2AALDH1A1TSHRCFDBTK | |
| SCHEMBL742052 | 0.86 | AKT1 (0.36) | CFDBTKNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |