Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414959 | 0.75 | PDE3B (0.56) | PDE3BPDE3AALDH1A1POLBKDM4E | |
| SCHEMBL7409986 | 0.72 | PDE3B (0.43) | PDE3BPDE3AALDH1A1HTTPOLB | |
| SCHEMBL7408010 | 0.67 | PDE3B (0.60) | PDE3BPDE3AALDH1A1HTTPOLB | |
| SCHEMBL15859207 | 0.66 | PDE3B (0.58) | PDE3BPDE3AALDH1A1HTTPOLB | |
| SCHEMBL11116678 | 0.63 | PDE3B (0.51) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28484553 | 0.62 | KDM4E (0.53) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL30640275 | 0.62 | KDM4E (0.53) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7282455 | 0.61 | ALDH1A1 (0.50) | PDE3BPDE3AALDH1A1HTTPOLB | |
| SCHEMBL11608889 | 0.61 | PDE3B (1.00) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10974105 | 0.59 | GABRA1 (0.48) | PDE3BPDE3AALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |