Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14374836 | 0.79 | KDM4E (0.51) | CDK1CDK2CSNK1DGSK3BCDK5 | |
| SCHEMBL7408010 | 0.79 | PDE3B (0.60) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9347456 | 0.78 | PLK4 (0.46) | PDE3BPDE3APLK4CHEK1AURKA | |
| SCHEMBL15859207 | 0.78 | PDE3B (0.58) | PDE3BPDE3AAURKAALDH1A1KDM4E | |
| SCHEMBL11116678 | 0.77 | PDE3B (0.51) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL24392630 | 0.75 | ALDH1A1 (0.49) | PDE3BPDE3APLK4CHEK1AURKA | |
| SCHEMBL7412993 | 0.75 | PDE3B (0.44) | PDE3BPDE3APLK4CHEK1AURKA | |
| SCHEMBL7409986 | 0.74 | PDE3B (0.43) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14374196 | 0.73 | MAT2A (0.46) | PDE3BPDE3AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14374256 | 0.72 | MAT2A (0.66) | CHEK1KDM4ESMN1; SMN2LMNACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |