Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 4/20 | 0.49 |
| ▸ | ITGAV | P06756 | 5/20 | 0.48 |
| ▸ | MMP10 | P09238 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.44 |
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418672 | 0.90 | MMP9 (0.57) | MMP9CA1CA2MMP1MMP2 | |
| SCHEMBL7414547 | 0.87 | MMP7 (0.54) | MMP9CA1CA2MMP7MMP10 | |
| SCHEMBL7411120 | 0.87 | MMP7 (0.54) | MMP9MMP7MMP10 | |
| SCHEMBL7416539 | 0.86 | MMP7 (0.61) | MMP9MMP13MMP7MMP10MAPT | |
| SCHEMBL7412866 | 0.86 | MMP7 (0.61) | MMP9CA1CA2MMP1MMP2 | |
| SCHEMBL7416682 | 0.85 | MMP7 (0.58) | MMP9CA1CA2MMP1MMP2 | |
| SCHEMBL7423461 | 0.85 | MMP7 (0.58) | MMP9CA1CA2MMP1MMP2 | |
| SCHEMBL31086909 | 0.84 | CA1 (0.54) | MMP9CA1CA2MMP1MMP2 | |
| SCHEMBL7411989 | 0.84 | MMP7 (0.49) | MMP9CA1CA2MMP1MMP2 | |
| SCHEMBL7414577 | 0.84 | MMP7 (0.49) | MMP9CA1CA2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |