Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8589749 | 0.98 | TLR8 (0.45) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL13529189 | 0.93 | TLR8 (0.44) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL22914584 | 0.86 | TYR (0.50) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL17190848 | 0.85 | PRKCI (0.40) | TSHRMEN1TP53MAPTHTT | |
| SCHEMBL10345219 | 0.81 | HTR2A (0.46) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL21392022 | 0.81 | ALOX5 (0.49) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL12798389 | 0.81 | HTR2A (0.46) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL207523 | 0.81 | HTR2A (0.46) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL5377545 | 0.81 | MAPT (0.49) | HTR2ATSHRMEN1TP53CYP3A4 | |
| SCHEMBL2018932 | 0.81 | HTR2A (0.46) | HTR2ATSHRMEN1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003740-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS | Abbott Laboratories (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999006397-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1999-02-11 | — | — | WO | disclosed |