Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 8/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10360472 | 0.68 | MAPT (0.46) | MAPTKMT2AKCNN4HTTCHRM3 | |
| SCHEMBL4525774 | 0.65 | CYP2B6 (0.47) | MAPTKMT2AKCNN4HTTCHRM3 | |
| SCHEMBL10360491 | 0.62 | MAPT (0.43) | MAPTKMT2AKCNN4HTTCHRM3 | |
| SCHEMBL27602772 | 0.61 | MAPT (0.50) | MAPTKMT2AKCNN4HTTCHRM3 | |
| SCHEMBL9273398 | 0.61 | KMT2A (0.46) | MAPTKMT2ACHRM3CHRM2CHRM1 | |
| SCHEMBL830791 | 0.61 | MAPT (0.60) | MAPTKMT2AKCNN4HTTCHRM3 | |
| SCHEMBL812971 | 0.61 | KCNN4 (0.76) | MAPTKMT2AKCNN4HTTKCNE1 | |
| SCHEMBL8717591 | 0.60 | MAPT (0.54) | MAPTKMT2AKCNN4HTTCHRM3 | |
| SCHEMBL1817734 | 0.59 | MAPT (0.58) | MAPTKMT2AKCNN4HTTKCNE1 | |
| SCHEMBL366365 | 0.59 | MAPT (0.58) | MAPTKMT2AKCNN4HTTKCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171423-A1 | CARBAMIC ACID DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063166-A1 | CARBAMIC ACID DERIVATIVES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-10-26 | — | — | WO | disclosed |